Psychedelic drugs on view on a table

Guide to Drug Combinations

Most people who use psychedelics do so for the first time without any prior knowledge about how to combine them or what effects they might have. Some visitors may be curious about how different psychedelics can be combined. We do not advocate or endorse any drug combinations. We offer this chart for educational purposes ONLY for those of you who want to experiment. Furthermore, we encourage individuals to use this information at their own risk and to try to be safe.

This chart should be used only as a guide and should not be taken as medical advice. If you are interested in experimenting with different combinations, please do so at your own risk and always under careful supervision from an experienced professional or doctor who knows what they are doing (such as yourself).

This is not an exhaustive list; it only includes some of the most popular pairings, as well as some less common combinations that have been reported by users.

Chart Guide to Drug Combinations

For example: If you’re interested in trying ayahuasca for the first time, it’s best that you drink it on its own so that you don’t have any other substances in your system when taking it. But if later on down the road you decide that there are some other substances (like cannabis or alcohol) that work well with ayahuasca then by all means go ahead and add them into your mix!

It is important to note that no two people will have the same experience with any given substance. The combination of drugs can also affect each person differently based on dosage and duration. Everyone has their own tolerance level which may vary depending on your body size and metabolism, as well as how much you’ve eaten before taking the drug(s). Therefore, we cannot make any recommendations about what combinations are “safe” or “best.”

However, there are some general guidelines that can help you determine if two or more substances might be a good complement for each other:

The first rule of combining psychedelics is to never mix them before you know how they work individually—meaning you should try them alone before trying them together so that you know what effects come from each one separately before mixing them up into something new.


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